ChloroquineV1, Main, Exploration, bibRecord, 001391

Improvements in Cystic Fibrosis Lung Disease and Airway Inflammation Associated with Etanercept Therapy for Rheumatoid Arthritis: A Case Report

Identifieur interne : 001391 ( Main/Exploration ); précédent : 001390; suivant : 001392

Improvements in Cystic Fibrosis Lung Disease and Airway Inflammation Associated with Etanercept Therapy for Rheumatoid Arthritis: A Case Report

Auteurs : S. Visser [Australie] ; M. Martin [Australie] ; D. J. Serisier [Australie]

Source :

Lung [ 0341-2040 ] ; 2012-10-01.

RBID : ISTEX:A6F2DCBC7A062DDD1902E023D690DD61A2B50847

English descriptors

KwdEn :
- Cystic fibrosis, Etanercept, Exacerbation, Lung function, Pulmonary, Sputum percent neutrophils, TNF-α antagonist.

Abstract

Abstract: Cystic fibrosis (CF) lung pathology is characterized by excessive neutrophilic inflammation and high tumor necrosis factor-alpha (TNF-α) levels. A cornerstone of CF management is reduction of the inflammatory burden in the lung. We present the case of a 19-year-old CF patient who demonstrated significant clinical improvement in her lung disease associated with a reduction in sputum percent neutrophils, following commencement of etanercept (TNF-α antagonist) for rheumatoid arthritis. She has not had any infectious complications or other significant adverse effects during 2 years of treatment. It may be time to reconsider TNF-α antagonists as potential anti-inflammatory agents for CF lung disease.

Url:

https://api.istex.fr/ark:/67375/VQC-GRDR3HQJ-9/fulltext.pdf

DOI: 10.1007/s00408-012-9393-9

Affiliations:

Australie

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000947
to stream Istex, to step Curation: 000947
to stream Istex, to step Checkpoint: 000400
to stream Main, to step Merge: 001392
to stream Main, to step Curation: 001391

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Cystic fibrosis (CF) lung pathology is characterized by excessive neutrophilic inflammation and high tumor necrosis factor-alpha (TNF-α) levels. A cornerstone of CF management is reduction of the inflammatory burden in the lung. We present the case of a 19-year-old CF patient who demonstrated significant clinical improvement in her lung disease associated with a reduction in sputum percent neutrophils, following commencement of etanercept (TNF-α antagonist) for rheumatoid arthritis. She has not had any infectious complications or other significant adverse effects during 2 years of treatment. It may be time to reconsider TNF-α antagonists as potential anti-inflammatory agents for CF lung disease.</div>
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Improvements in Cystic Fibrosis Lung Disease and Airway Inflammation Associated with Etanercept Therapy for Rheumatoid Arthritis: A Case Report

Improvements in Cystic Fibrosis Lung Disease and Airway Inflammation Associated with Etanercept Therapy for Rheumatoid Arthritis: A Case Report

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri